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Zelboraf вызывает серьезные побочные эффекты

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Zelboraf вызывает серьезные побочные эффекты

Недавно одобренный препарат vemurafenib (Zelboraf) расценивался специалистами как прорыв в лечении меланомы. Но примерно у четверти пациентов, которые принимают это лекарст...

Услуги Соцсети
Новое исследование ученых из Jonsson Comprehensive Cancer Center в Университете Калифорнии (Лос-Анджелес) и его коллег идентифицирует конкретный генетический механизм, который вызывает этот побочный эффект.

«Мы обнаружили, что vemurafenib блокирует мутацию, которая ведет к росту меланомы, но когда у пациентов клетки кожи с другой мутацией, которая, вероятно, вызвана пребыванием на солнце, то препарат имеет прямо противоположный эффект и стимулирует эти плоские раковые клетки расти», - комментирует д-р Антонио Рибас, один из авторов исследования.

Более того, данные свидетельствуют о том, что объединение vemurafenib, ингибитора BRAF с препаратом под названием ингибитор МЕК – который блокирует другие мутации - может не только предотвратить этот побочный эффект, но также привести к еще более эффективному лечению меланомы. Однако, как уточняют ученые, это еще должно быть доказано в клинических испытаниях.

Исследование опубликовано в журнале New England Journal of Medicine. В нем Рибас и его коллеги проанализировали клетки из плоскоклеточного повреждения у пациентов, получавших vemurafenib, чтобы найти специфические генетические мутации.

Из 21 образца опухолей у 13 исследователи обнаружили так называемую мутацию RAS, которая предрасполагает к развитию плоскоклеточного рака. В отдельном наборе из 14 образцов только 8 имели мутацию RAS.

"Наши данные показывают, что около 60% пациентов, у которых развивается плоскоклеточный рак, принимают ингибитор BRAF и у них происходит мутация RAS», - комментирует Рибас.

В экспериментах на мышах с мутацией RAS исследователи показали, что комбинация ингибитора BRAF и ингибитора МЕК успешно заблокировала рост плоскоклеточного рака.

Этот результат, возможно, потребуется репликации в организме человека, так как в ряде случаев то, что эффективно на животных, не всегда так же эффективно для лечения людей.
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    [TIMESTAMP_X] => 23.01.2012 16:32:09
    [DETAIL_PAGE_URL] => /cosmetology/news/181509/
    [PREVIEW_TEXT] => Недавно одобренный препарат vemurafenib (Zelboraf) расценивался специалистами как прорыв в лечении меланомы. Но примерно у четверти пациентов, которые принимают это лекарство, развивается серьезный побочный эффект – вторичный рак кожи, который называется плоскоклеточный рак, пишет портал usatoday.com
    [PICTURE] => /upload/iblock/2cf/wefweff2334.jpg
    [keywords] => 
    [description] => 
    [title] => 
)

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